Cutaneous adverse drug reactions to lamotrigine and human leukocyte antigen typing in North Indian patients: A case series
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چکیده
منابع مشابه
Cutaneous Adverse Drug Reactions to Lamotrigine and Human Leukocyte Antigen Typing in North Indian Patients: A Case Series
Cutaneous adverse drug reaction (cADR) has limited epidemiological data in India. The older antiepileptic drugs, i.e., carbamazepine, phenytoin, valproic acid, phenobarbitone, etc., induce severe cADRs that have a strong associated with human leukocyte antigen (HLA)-related genetic risk factors. There is also evidence of association of certain HLA alleles with lamotrigine (LTG)-induced cADRs, b...
متن کاملSpectrum of Cutaneous Adverse Reactions to Levetiracetam and Human Leukocyte Antigen Typing in North-Indian Patients
BACKGROUND AND PURPOSE Aromatic antiepileptic drugs are frequently implicated for cutaneous adverse drug reactions (cADRs); there are case-reports of even severe reactions like drug reaction eosinophilia and systemic symptoms (DRESS) and Stevens Johnson syndrome (SJS)-toxic epidermal necrolysis with Levetiracetam (LEV). Certain human leukocyte antigen (HLA)-alleles have strong association with ...
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Background: Adverse cutaneous drug reactions are unwarranted effects of modern medicine. These unfortunate events can assume any morphology from simple exanthem to full blown toxic epidermal necrolysis (TEN), and can simulate and mimic many diseases. Sometimes it is difficult to recognize the cause, but they may be due to polypharmacy or self-administration of medications. The analytical data f...
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| August 2014 | 798 Finally, the authors detected a higher prevalence of more serious and life-threatening types of ACDR like Stevens Johnson and toxic epidermal necrolysis in their study. This finding is so important and may be due to the difference in type and potency of metabolic pathways in Iranian patients due to their ethnic groups, or it may be due to not including the above mentioned ri...
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ژورنال
عنوان ژورنال: Annals of Indian Academy of Neurology
سال: 2017
ISSN: 0972-2327
DOI: 10.4103/aian.aian_234_17